According to the National Institutes of Health, about half of people who misuse prescription pain medication get them without a prescription from a friend or relative. And almost 50% of people in the United States have used at least one prescription drug in the past 30 days, according to the Centers for Disease Control and Prevention (CDC).   

One easy way to prevent drug misuse is to properly dispose of any unused or expired medications through the U.S. Drug Enforcement Administration (DEA)’s biannual National Prescription Drug Take Back Day at select locations from 10 a.m. to 2 p.m. on Saturday, April 25.    

What’s National Drug Take Back Day?  

National Drug Take Back Day is a concerted effort by health care organizations to encourage families to clean out their medicine cabinets and prevent drug misuse, poisoning or accidental overdose. However, this awareness day isn’t the only day to drop off unused or expired medication, as there are also year-round locations to drop off various types of prescription and over-the-counter medicines — including aerosols, capsules, creams, gels, inhalers, liquids, patches, pills and powders.  

So you shouldn’t toss your meds in the garbage, which ends up in landfills, or down the toilet, which can be dangerous to water supplies and may cause plumbing issues down the road.   

How to drop off medications 

Dropping off medications at one of the more than 4,000 participating pharmacies, hospitals and businesses around the country (or 17,000 registered pharmacies that accept collections any time of year) is easy, convenient and anonymous — there’s no fee and no need for ID. Simply package your medicines in the original containers (or, if you’ve tossed the original packaging, place your medications in quart-sized plastic bags), and drop the drugs into designated, usually self-serve drop boxes. Make sure to check the instructions for your local drop-off locations to confirm what medications they accept, as certain locations may not accept some medications. Learn more about how and where to safely dispose of unused medications at the FDA’s website.   

Making an impact 

In October 2025 alone, 286 tons of unused drugs were collected as part of National Drug Take Back Day, and since the program started nationwide in 2010, more than 10,000 tons have been collected.   

Secure and safeguard your current medications 

Now is also a good time to evaluate the storage of your current medications — or the medications of a loved one you care for. Keep them out of the reach of vulnerable adults, children and pets, and make sure you follow the directions on the label carefully. Don’t be scared to ask your doctor or pharmacist questions. The CDC also recommends securing prescription narcotics, such as morphine, opioids or codeine, in a locked cabinet or drawer.